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LOPRESSOR (METOPROLOL TARTRATE) TABLETS AND INJECTIONS: PRESCRIBING INFORMATION
Lopressor (metoprolol tartrate) is a selective beta1-adrenoreceptor blocking agent, available as 50 mg and 100 mg tablets for oral administration and in 5 ml ampuls for intravenous
administration. Each ampul contains a sterile solution of metoprolol tartrate 5 mg, sodium chloride 45 mg, and water for injection.
Metoprolol tartrate is a white, practically odorless, crystalline powder with a molecular weight of 684.82. It is very soluble in water; freely soluble in methylene chloride, in chloroform,
and in alcohol; slightly soluble in acetone; and insoluble in ether.
Inactive Ingredients: Tablets contain cellulose compounds, colloidal silicon dioxide, D&C Red No. 30 aluminum lake (50-mg tablets), FD&C Blue No. 2 aluminum lake (100-mg tablets), lactose, magnesium stearate, polyethylene glycol, propylene glycol, povidone, sodium starch glycolate, talc, and titanium dioxide.
Lopressor clinical pharmacology
INDICATIONS AND USAGE
Lopressor tablets are indicated for the treatment of hypertension. They may be used alone or in combination with other antihypertensive agents.
Lopressor is indicated in the long-term treatment of angina pectoris.
Lopressor tablets and injections are indicated in the treatment of hemodynamically stable patients with definite or suspected acute myocardial infarction to reduce cardiovascular mortality.
Treatment with intravenous Lopressor can be initiated as soon as the patient's clinical condition allows. Alternatively, treatment can begin within 3 to 10 days of the acute event.
Hypertension and Angina
Lopressor is contraindicated in sinus bradycardia, heart block greater than first degree, cardiogenic shock, and overt cardiac failure.
Hypersensitivity to Lopressor and related derivatives, or to any of the excipients; hypersensitivity to other beta blockers (cross sensitivity between beta blockers can occur).
Severe peripheral arterial circulatory disorders.
Lopressor is contraindicated in patients with a heart rate < 45 beats/min; second- and third-degree heart block; significant first-degree heart block (P-R interval .0.24 sec); systolic blood pressure < 100 mmHg; or moderate-to-severe cardiac failure.
Lopressor drug interactions
USE IN SPECIAL POPULATIONS
Lopressor use in special populations
Lopressor adverse reactions
DOSAGE AND ADMINISTRATION
Lopressor dosage and administration
Metoprolol Tartrate tablets, USP
Tablets 50 mg – capsule-shaped, biconvex, pink, scored (imprinted GEIGY on one side and 51 twice on the scored side).
Tablets 100 mg – capsule-shaped, biconvex, light blue, scored (imprinted GEIGY on one side and 71 twice on the scored side).
Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Protect from moisture.
Dispense in tight, light-resistant container (USP).
Metoprolol Tartrate injection, USP
Ampuls 5 ml – each containing 5 mg of metoprolol tartrate.
Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) [see USP Controlled Room Temperature]. Protect from light.
Lopressor tablets and injections are manufactured and distributed by Novartis pharmaceutical company.
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